INDUCTION OF CYTOCHROME-P-450 IN SIGMODON HISPIDUS (COTTON RATS) EXPOSED TO DIETARY AROCLOR-1254

Authors
HENNEMAN JR FOX SD LUBET RA WARD JM NIMS RW
Citation
Jr. Henneman et al., INDUCTION OF CYTOCHROME-P-450 IN SIGMODON HISPIDUS (COTTON RATS) EXPOSED TO DIETARY AROCLOR-1254, Journal of toxicology and environmental health, 41(3), 1994, pp. 369-386
Citations number
33
Categorie Soggetti
Toxicology,"Environmental Sciences","Public, Environmental & Occupation Heath
Journal title
Journal of toxicology and environmental health → ACNP
ISSN journal
00984108
Volume
41
Issue
3
Year of publication
1994
Pages
369 - 386
Database
ISI
SICI code
0098-4108(1994)41:3<369:IOCISH>2.0.ZU;2-E
Abstract
The induction of immunoreactive cytochrome P-450 protein and associate d catalytic activities in 10-wk-old male and female Sigmodon hispidus (cotton rats) exposed for 2 wk to low dietary levels of Aroclor 1254 ( 0.33, 1.0, 3.3, 10, and 33 ppm), or the prototype P-450 inducers pheno barbital, DDT, clotrimazole, and beta-naphthoflavone was examined. Eth oxy(ETR), methoxy- (MTR), pentoxy- (PTR), and benzyloxyresorufin (BZR) O-dealkylation activities were significantly increased at 0.33 ppm Ar oclor for males and 1.0 ppm for females,