PSORALEN FATTY-ACID CYCLOADDUCTS ACTIVATE PROTEIN-KINASE-C (PKC) IN HUMAN PLATELETS

Authors
CAFFIERI S RUZZENE M GUERRA B FRANK S VEDALDI D DALLACQUA F
Citation
S. Caffieri et al., PSORALEN FATTY-ACID CYCLOADDUCTS ACTIVATE PROTEIN-KINASE-C (PKC) IN HUMAN PLATELETS, Journal of photochemistry and photobiology.B, Biology, 22(3), 1994, pp. 253-256
Citations number
19
Categorie Soggetti
Biophysics,Biology
Journal title
Journal of photochemistry and photobiology.B, Biology → ACNP
ISSN journal
10111344
Volume
22
Issue
3
Year of publication
1994
Pages
253 - 256
Database
ISI
SICI code
1011-1344(1994)22:3<253:PFCAP(>2.0.ZU;2-9
Abstract
The C-4-photocycloadduct psoralen-linolenic acid activates protein kin ase C (PKC), in human platelets, which in turn phosphorylates 47 kDa p rotein, representing its major substrate in these cells. This behaviou r is similar to that shown by diacylglycerol, a main second messenger responsible of various biological effects, e.g. of melanogenesis.