TOTAL SYNTHESIS OF THE ETHANOL-INDUCIBLE, PROINFLAMMATORY AUTACOID 3(S)-HYDROXY-LEUKOTRIENE B-4 (3-OH-LTB(4)) AND ANALOGS

Authors
CHAUHAN K BHATT RK FALCK JR CAPDEVILA JH
Citation
K. Chauhan et al., TOTAL SYNTHESIS OF THE ETHANOL-INDUCIBLE, PROINFLAMMATORY AUTACOID 3(S)-HYDROXY-LEUKOTRIENE B-4 (3-OH-LTB(4)) AND ANALOGS, Tetrahedron letters, 35(12), 1994, pp. 1825-1828
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
12
Year of publication
1994
Pages
1825 - 1828
Database
ISI
SICI code
0040-4039(1994)35:12<1825:TSOTEP>2.0.ZU;2-V
Abstract
3(S)-Hydroxy-Leukotriene B-4 (1a), its 3(R)-epimer 1b, and a 14,15-ace tylenic analogue were efficiently prepared via chelation-controlled re duction of ketone 12, obtained by acetylide addition to chiral beta-hy droxylactones 7/9.