INDIRECT T-CELL ALLORECOGNITION - PERSPECTIVES FOR PEPTIDE-BASED THERAPY IN TRANSPLANTATION

Indirect allorecognition is nit important component of allotransplant rejection. Although the initial indirect alloresponse is limited to a fete dominant determinants on donor major histocompatibility complex ( MHC) molecules, subsequent spreading to additional determinants on rec ipient and donor antigens is common. Gilles Benichou and colleagues di scuss the mechanisms by which immunodominance is acquired or disrupted in indirect alloresponses, and examine the implications for the desig n of peptide-based selective immunotherapy in transplantation.