IMPLICATIONS FOR IMMUNOSURVEILLANCE OF ALTERED HLA CLASS-I PHENOTYPESIN HUMAN TUMORS

Authors
GARRIDO F RUIZCABELLO F CABRERA T PEREZVILLAR JJ LOPEZBOTET M DUGGANKEEN M STERN PL
Citation
F. Garrido et al., IMPLICATIONS FOR IMMUNOSURVEILLANCE OF ALTERED HLA CLASS-I PHENOTYPESIN HUMAN TUMORS, Immunology today, 18(2), 1997, pp. 89-95
Citations number
68
Categorie Soggetti
Immunology
Journal title
Immunology today → ACNP
ISSN journal
01675699
Volume
18
Issue
2
Year of publication
1997
Pages
89 - 95
Database
ISI
SICI code
0167-5699(1997)18:2<89:IFIOAH>2.0.ZU;2-O
Abstract
HLA class I downregulation is It frequent event associated with tumour invasion and development. Altered HLA class I tumour phenotypes can h ave profound effects on T-cell and natural killer (NK)-cell antitumour responses. Here, Federico Garrido and colleagues analyse these altere d tumour phenotypes in detail, indicating their potential relevance fo r implementation of immunotherapeutic protocols and strategies to over come tumour escape mechanisms.