COMPARISON OF MICELLAR ELECTROKINETIC CAPILLARY CHROMATOGRAPHY AND HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY ON THE SEPARATION AND DETERMINATION OF CAFFEINE AND ITS ANALOGS IN PHARMACEUTICAL TABLETS

Authors
SUN P MARIANO GJ BARKER G HARTWICK RA
Citation
P. Sun et al., COMPARISON OF MICELLAR ELECTROKINETIC CAPILLARY CHROMATOGRAPHY AND HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY ON THE SEPARATION AND DETERMINATION OF CAFFEINE AND ITS ANALOGS IN PHARMACEUTICAL TABLETS, Analytical letters, 27(5), 1994, pp. 927-937
Citations number
14
Categorie Soggetti
Chemistry Analytical
Journal title
Analytical letters → ACNP
ISSN journal
00032719
Volume
27
Issue
5
Year of publication
1994
Pages
927 - 937
Database
ISI
SICI code
0003-2719(1994)27:5<927:COMECC>2.0.ZU;2-5
Abstract
Micellar electrokinetic capillary chromatography (MEKC) is investigate d for the separation and determination of caffeine and its analogues a s a complementary method to high-performance liquid chromatography (HP LC). Separation efficiency, resolution, analysis time, sample recovery and reproducibility are examined by comparing MEKC and HPLC in parall el analysis. The results show that MEKC is a useful economic technique in pharmaceutical analysis, yielding high efficiency, resolution and short analysis times.