F. Fornai et al., FOCAL INTRACEREBRAL ELEVATION OF L-LACTATE IS ANTICONVULSANT, European journal of pharmacology, 254(3), 1994, pp. 180000001-180000002
Sodium lactate (pH 7.0) infused over the area tempestas, an epileptoge
nic site in the prepiriform cortex, protected rats from limbic motor s
eizures induced by infusion of a GABA receptor antagonist in area temp
estas. The anticonvulsant action, which was anatomically site-specific
and reversible, persisted for 90 min. Infusions of sodium acetate (pH
5.5 or 7.0) over area tempestas were not anticonvulsant. Our findings
suggest that lactate can modulate neural activity and that increased
cerebral lactate as occurs with epileptic seizures, may limit the dura
tion and spread of seizure activity.