THE NONAQUEOUS TITRIMETRIC ASSAY OF SELECTED ANTIBIOTICS USING TETRA-N-BUTYLAMMONIUM HYDROXIDE AS TITRANT

This study was carried out to develop a potentiometric titration metho d in non-aqueous media for the determination of some commonly used ant ibiotics. For this purpose, five antibiotics, namely ampicillin, amoxy cillin trihydrate, rifampin, netilmicin sulphate and ciproflaxacin hyd rochloride, were potentiometrically titrated using pyridine as solvent and tetrabutylammonium hydroxide as titrant, at 25-degrees-C and unde r a nitrogen atmosphere. The method was found to be highly accurate an d precise having a relative standard deviation of less than 1.0%. Also it was shown that the method could be successfully applied to assay o f commercial pharmaceuticals containing the above-mentioned antibiotic s. The results of recovery studies for standard additions in pharmaceu tical preparations were satisfactory. The proposed method is simple, r apid and sufficiently precise for quality control purposes.