CARDIAC MECHANOSENSITIVITY AND STRETCH-ACTIVATED ION CHANNELS

Authors
BETT GCL SACHS F
Citation
Gcl. Bett et F. Sachs, CARDIAC MECHANOSENSITIVITY AND STRETCH-ACTIVATED ION CHANNELS, Trends in cardiovascular medicine, 7(1), 1997, pp. 4-8
Citations number
65
Categorie Soggetti
Cardiac & Cardiovascular System
Journal title
Trends in cardiovascular medicine → ACNP
ISSN journal
10501738
Volume
7
Issue
1
Year of publication
1997
Pages
4 - 8
Database
ISI
SICI code
1050-1738(1997)7:1<4:CMASIC>2.0.ZU;2-C
Abstract
Mechanosensitivity is a ubiquitous property of cells, and mechanosensi tive ion channels (MSCs) are hypothesized to be the transducers. In th e heart MSCs are likely to account for changes in beating rate as a fu nction of filling and for initiating stretch-induced arrhythmias (for example, following a myocardial infarction). Pharmacological agents th at affect MSCs may provide a new class of antiarrhythmic drugs. (C) 19 97, Elsevier Science Inc.