UNCOUPLING OF OXIDATIVE-PHOSPHORYLATION BY FATTY-ACIDS IN LIVER AND MUSCLE MITOCHONDRIA

Authors
MOKHOVA EN STARKOV AA BOBYLEVA VA
Citation
En. Mokhova et al., UNCOUPLING OF OXIDATIVE-PHOSPHORYLATION BY FATTY-ACIDS IN LIVER AND MUSCLE MITOCHONDRIA, Biochemistry, 58(10), 1993, pp. 1105-1112
Citations number
87
Categorie Soggetti
Biology
Journal title
Biochemistry → ACNP
ISSN journal
00062979
Volume
58
Issue
10
Year of publication
1993
Pages
1105 - 1112
Database
ISI
SICI code
0006-2979(1993)58:10<1105:UOOBFI>2.0.ZU;2-Q
Abstract
Pathways and mechanisms of oxidative phosphorylation uncoupling by lon g-chain fatty acids in liver, heart, and skeletal muscle mitochondria are considered It is concluded that there are at least three different pathways of fatty acid uncoupling, namely: 1) a Ca2+-dependent cyclos porin A-sensitive pathway; 2) uncoupling which is inhibited by carboxy atractylate or other inhibitors of the ATP/ADP-antiporter; 3) uncoupli ng due to the low protonophoric activity of fatty acids.