DYNAMIC ENDOSCOPIC MANOMETRY OF THE RESPONSE TO SECRETIN IN PATIENTS WITH CHRONIC-PANCREATITIS

Authors
Citation
R. Laugier, DYNAMIC ENDOSCOPIC MANOMETRY OF THE RESPONSE TO SECRETIN IN PATIENTS WITH CHRONIC-PANCREATITIS, Endoscopy, 26(2), 1994, pp. 222-227
Citations number
32
Categorie Soggetti
Gastroenterology & Hepatology
Journal title
ISSN journal
0013726X
Volume
26
Issue
2
Year of publication
1994
Pages
222 - 227
Database
ISI
SICI code
0013-726X(1994)26:2<222:DEMOTR>2.0.ZU;2-J
Abstract
Endoscopic manometry of the spincter of Oddi and the main pancreatic d uct (MPD) was performed before and after intravenous injection of secr etin (1 CU/kg) in 15 control subjects and 19 patients with chronic pan creatitis. Secretin significantly but transiently enhanced the MPD pre ssure in the controls, whereas chronic pancreatitis patients had an el evated basal MPD pressure and a manometric pattern of sphincter of Odd i dyskinesia. The secretin-induced MPD pressure was also elevated and more sustained in chronic pancreatitis patients compared to controls. No influence of the etiology or MPD ductal diameter was found, but the duration of the disease correlated significantly to the pressure resp onse to secretin in patients. The pressure enhancement was most impres sive in chronic pancreatitis of recent onset (less than four years), w hereas it was minimal or normal in later stages of the disease. This d ynamic manometric test reliably demonstrates sphincter of Oddi dysfunc tion and an altered response to secretin. The test could have a role t o play in the explanation of progressive MPD dilatation as well as in the early diagnosis of chronic pancreatitis.