THE STRESS-RESPONSE TO LAPAROSCOPIC CHOLECYSTECTOMY - INVESTIGATION OF ENDOCRINE PARAMETERS

Laparoscopic cholecystectomy, as a typical example of minimal invasive surgery, is associated with low complication rates and minimal patien t discomfort, and provides the same safety as conventional cholecystec tomy. In the present prospective observational study, endocrine parame ters as indicators for stress response were measured. We investigated 53 patients with laparoscopy cholecystectomy and 12 patients with conv entional cholecystectomy. Blood samples were taken pre-, peri-, and po stoperatively for measurement of ACTH, cortisol, prolactin, and growth hormone. General anesthesia followed a standardized protocol. The inc rease in all stress hormones did not differ between patients in the tw o groups, and was comparable with that reported in the literature and the findings of our own previous studies in patients undergoing conven tional cholecystectomy and elective colon resection. We conclude that laparoscopic cholecystectomy is associated with a pronounced endocrine stress response that does not account for the observed differences in the peri- and postoperative complication rate or patient comfort.