DIFFERENTIAL T-CELL EXPRESSION OF LFA-1 IN RESIDENTS FROM AFRICA AND DENMARK - DESCRIPTION OF THE PHENOMENON AND ITS POSSIBLE BASIS

All circulating T cells constitutively express the adhesion molecule l eukocyte function-associated antigen 1 (LFA-1; CD11a/CD18) at either l ow or high surface density. In the present paper we have compared the expression of the LFA-1 alpha-chain CD11a on peripheral T cells obtain ed from indigenous Africans with permanent residence in Africa to T ce lls from indigenous Danes with permanent residence in Denmark. The Afr icans had a higher percentage of T cells with high CD11a expression th an did Danish donors. The difference was evident in both the CD3(+), C D4(+), and CD8(+) subsets. The difference did not appear to reflect a higher degree of peripheral T-cell activation in the African donors, a s T cell expression of the activation marker IL-2 receptor (CD25) was similar in the two groups. Furthermore, we observed no apparent correl ation between CD3(+) CD11a(hi) and CD3(+) CD25(+) values in individual donors LFA-1 expression on T cells obtained from expatriate Africans with long-term residence in Denmark resembled that of Danish permanent residents more than that of Africans with permanent residence in Afri ca. In addition, T cells obtained from two expatriate Danes with long- term residence in rural Africa were phenotypically similar to those fr om African permanent residents. The data suggest that the observed dif ference is environmental rather than ethnic and may reflect the degree of exposure to infectious agents.