COMPARATIVE CHROMOSOME PAINTING DISCLOSES HOMOLOGOUS SEGMENTS IN DISTANTLY RELATED MAMMALS

Comparative chromosome painting, termed Z00-FISH, using DNA libraries from flow sorted human chromosomes 1, 16, 17 and X, and mouse chromoso me 11 discloses the presence of syntenic groups in distantly related m ammalian orders ranging from primates (Home sapiens), rodents (Mus mus culus), even-toed ungulates (Muntiacus muntjak vaginalis and Muntiacus reevesi) and whales (Balaenoptera physalus). These mammalian orders h ave evolved separately for 55-80 million years (Myr). We conclude that Z00-FISH can be used to generate comparative chromosome maps of a lar ge number of mammalian species.