INTEGRATED HUMAN GENOME-WIDE MAPS CONSTRUCTED USING THE CEPH REFERENCE PANEL

High resolution linkage maps have proven to be invaluable tools in gen etic investigations. We have assembled a collection of genetic maps co nstructed from primary data collected from investigators performing ge notyping using the Centre Etude Polymorphism Humain (CEPH) reference p edigree panel. These maps were constructed using a rigorous, semi-auto mated map construction algorithm that evaluates the integrity of the m aps during construction. Two classes of maps were produced: a high con fidence ''skeletal'' set composed of 544 PCR based markers, and a more highly annotated ''framework'' set containing maps of 1,123 markers. Genetic map locations within the framework maps are provided for an ad ditional 1,758 loci without statistically unique interval assignments.