Y. Denizot et al., PAF AND HEMATOPOIESIS .4. PLATELET-ACTIVATING-FACTOR INCREASES DNA-SYNTHESIS IN HUMAN BONE-MARROW CELLS, Journal of lipid mediators and cell signalling, 15(1), 1996, pp. 1-4
Platelet-activating factor (PAF) is present in human bone marrow leadi
ng us to investigate its effect on human bone marrow cell proliferatio
n. While PAF (0.1 mu M to 1 nM) stimulates the incorporation of [H-3]t
hymidine by freshly isolated adherent human bone marrow cells, PAF has
no effect on non adherent cells. A non-metabolizable PAF agonist is m
ore potent than PAF to stimulate thymidine incorporation in adherent c
ells. The precise role of PAF in human haematopoiesis in vivo remains
to be clarified.