PAF AND HEMATOPOIESIS .4. PLATELET-ACTIVATING-FACTOR INCREASES DNA-SYNTHESIS IN HUMAN BONE-MARROW CELLS

Authors
DENIZOT Y DUPUIS F TRIMOREAU F VERGER C ALLEGRAUD A PRALORAN V
Citation
Y. Denizot et al., PAF AND HEMATOPOIESIS .4. PLATELET-ACTIVATING-FACTOR INCREASES DNA-SYNTHESIS IN HUMAN BONE-MARROW CELLS, Journal of lipid mediators and cell signalling, 15(1), 1996, pp. 1-4
Citations number
8
Categorie Soggetti
Biology,"Cell Biology
Journal title
Journal of lipid mediators and cell signalling → ACNP
ISSN journal
09297855
Volume
15
Issue
1
Year of publication
1996
Pages
1 - 4
Database
ISI
SICI code
0929-7855(1996)15:1<1:PAH.PI>2.0.ZU;2-6
Abstract
Platelet-activating factor (PAF) is present in human bone marrow leadi ng us to investigate its effect on human bone marrow cell proliferatio n. While PAF (0.1 mu M to 1 nM) stimulates the incorporation of [H-3]t hymidine by freshly isolated adherent human bone marrow cells, PAF has no effect on non adherent cells. A non-metabolizable PAF agonist is m ore potent than PAF to stimulate thymidine incorporation in adherent c ells. The precise role of PAF in human haematopoiesis in vivo remains to be clarified.