EFFECT OF SPLEEN-CELL POPULATIONS ON RESOLUTION OF CRYPTOSPORIDIUM-PARVUM INFECTION IN SCID MICE

Authors
PERRYMAN LE MASON PH CHRISP CE
Citation
Le. Perryman et al., EFFECT OF SPLEEN-CELL POPULATIONS ON RESOLUTION OF CRYPTOSPORIDIUM-PARVUM INFECTION IN SCID MICE, Infection and immunity, 62(4), 1994, pp. 1474-1477
Citations number
37
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
62
Issue
4
Year of publication
1994
Pages
1474 - 1477
Database
ISI
SICI code
0019-9567(1994)62:4<1474:EOSPOR>2.0.ZU;2-E
Abstract
Persistent infection was established in SCID mice given 10(7) Cryptosp oridium parvum oocysts. Nine groups of infected SCID mice were inocula ted with 10(6), 10(5), or 10(4) total spleen cells, CD8-depleted splee n cells, or CD4-depleted spleen cells from naive BALB/c donors. Infect ion was significantly reduced in all treatment groups. The most profou nd effect occurred with spleen cell preparations containing CD4 T lymp hocytes but depleted of CD8 T lymphocytes.