PNEUMOLYSIN STIMULATES PRODUCTION OF TUMOR-NECROSIS-FACTOR-ALPHA AND INTERLEUKIN-1-BETA BY HUMAN MONONUCLEAR PHAGOCYTES

Authors
HOULDSWORTH S ANDREW PW MITCHELL TJ
Citation
S. Houldsworth et al., PNEUMOLYSIN STIMULATES PRODUCTION OF TUMOR-NECROSIS-FACTOR-ALPHA AND INTERLEUKIN-1-BETA BY HUMAN MONONUCLEAR PHAGOCYTES, Infection and immunity, 62(4), 1994, pp. 1501-1503
Citations number
22
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
62
Issue
4
Year of publication
1994
Pages
1501 - 1503
Database
ISI
SICI code
0019-9567(1994)62:4<1501:PSPOTA>2.0.ZU;2-T
Abstract
Human peripheral blood monocytes and a human monocyte cell line were e xposed to the toxin pneumolysin. Pneumolysin-exposed cells produced si gnificantly larger amounts of tumor necrosis factor alpha and interleu kin-1 beta than cells not exposed to the toxin. The viability of cells was not affected by the concentrations of pneumolysin used in the exp eriments.