SYNTHESIS OF 4-ARYL-1-LAMBDA(2),2-LAMBDA( 4)-DITHIA-3,4-DIAZA-BUTA-1,2-DIENES, A NEW DITHIADIAZABUTADIENE SYSTEM

Authors
HESS U HOMANN T KOMENDA J
Citation
U. Hess et al., SYNTHESIS OF 4-ARYL-1-LAMBDA(2),2-LAMBDA( 4)-DITHIA-3,4-DIAZA-BUTA-1,2-DIENES, A NEW DITHIADIAZABUTADIENE SYSTEM, Die Pharmazie, 49(2-3), 1994, pp. 121-125
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Die Pharmazie → ACNP
ISSN journal
00317144
Volume
49
Issue
2-3
Year of publication
1994
Pages
121 - 125
Database
ISI
SICI code
0031-7144(1994)49:2-3<121:SO44>2.0.ZU;2-A
Abstract
4-Aryl-1 lambda(2),2 lambda(4)-dithia-3,4-diaza-buta-1,2 1a-12a as rep resentatives of a dithiadiazabutadiene structure in which sulphur occu pies a different oxidation number are synthesized by reaction of diazo tated acceptor-substituted aryl- and hetarylamines 1-12 with thiosulfa tes or disodium disulfide in strong acid solution. For some examples a first pharmacological test indicate an immune-stimulating effect. Ana lytical examination as well as MNDO calculation which give some mechan istical insight, supplements the new synthesis.