Ae. Karger et al., DIRECT CHIRAL SEPARATION OF TIAPROFEN, CA RPROFEN AND FLURBIPROFEN BYCYCLODEXTRIN-MODIFIED CAPILLARY ELECTROPHORESIS, Die Pharmazie, 49(2-3), 1994, pp. 155-159
The separation of non-steroidal anti-inflammatory agents by capillary
electrophoresis was investigated. Eight representative 2-arylpropionic
acid derived drugs were baseline separated by micellar electrokinetic
chromatography (MEKC). Based on the MEKC conditions, a variety of cyc
lodextrins (CD) and their derivatives were screened for chiral separat
ion of the racemic drugs. Enantioselectivity was found for gamma-CD an
d it's derivatives but not for alpha- or beta-CD Out of the 8 racemic
compounds investigated, tiaprofen, flurbiprofen and carprofen enantiom
ers were separated with resolution of 0.8, 0.8 and 1.3, respectively.