DIRECT CHIRAL SEPARATION OF TIAPROFEN, CA RPROFEN AND FLURBIPROFEN BYCYCLODEXTRIN-MODIFIED CAPILLARY ELECTROPHORESIS

Authors
KARGER AE STOLL E HANSEL W
Citation
Ae. Karger et al., DIRECT CHIRAL SEPARATION OF TIAPROFEN, CA RPROFEN AND FLURBIPROFEN BYCYCLODEXTRIN-MODIFIED CAPILLARY ELECTROPHORESIS, Die Pharmazie, 49(2-3), 1994, pp. 155-159
Citations number
12
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Die Pharmazie → ACNP
ISSN journal
00317144
Volume
49
Issue
2-3
Year of publication
1994
Pages
155 - 159
Database
ISI
SICI code
0031-7144(1994)49:2-3<155:DCSOTC>2.0.ZU;2-A
Abstract
The separation of non-steroidal anti-inflammatory agents by capillary electrophoresis was investigated. Eight representative 2-arylpropionic acid derived drugs were baseline separated by micellar electrokinetic chromatography (MEKC). Based on the MEKC conditions, a variety of cyc lodextrins (CD) and their derivatives were screened for chiral separat ion of the racemic drugs. Enantioselectivity was found for gamma-CD an d it's derivatives but not for alpha- or beta-CD Out of the 8 racemic compounds investigated, tiaprofen, flurbiprofen and carprofen enantiom ers were separated with resolution of 0.8, 0.8 and 1.3, respectively.