PARVIFLORACIN AND PARVIFLORIN - CYTOTOXIC BISTETRAHYDROFURAN ACETOGENINS WITH 35 CARBONS FROM ASIMINA-PARVIFLORA (ANNONACEAE)

Using lethality to brine shrimp, activity-directed fractionation of ex tracts of Asimina parviflora (Michx.) Dunal. (Annonaceae) has led to t he isolation of two new and four known acetogenins (1-6). Compound 1, parvifloracin, is the first nonadjacent bistetrahydrofuran acetogenin with 35 carbons. Compound 2, parviflorin, is an unusual adjacent biste trahydrofuran acetogenin with 35 carbons. Bullatacin (3), molvizarin ( 4), annonacin (5), and goniothalamicin (6) are also reported for the f irst time from this plant. Brine shrimp lethality test data and compar ative cytotoxicities of 1-6 against three human solid tumor cell lines are presented.