The processes known as positive and negative selection that determine
the fate of T and B cells depend on finely tuned interactions between
the T-cell receptor complex, CD4 or CD8 co-receptors, and a peptide-MH
C complex. New work indicates that the avidity of this interaction is
critical in the determination of its outcome. The effects of these int
eractions on developing thymocytes are also a function of the unique a
ctivation properties with which thymocytes are programed just before t
hey undergo selection.