T-CELL DEVELOPMENT AND FUNCTION IN GENE-KNOCKOUT MICE

Authors
YEUNG RSM PENNINGER J MAK TW
Citation
Rsm. Yeung et al., T-CELL DEVELOPMENT AND FUNCTION IN GENE-KNOCKOUT MICE, Current opinion in immunology, 6(2), 1994, pp. 298-307
Citations number
107
Categorie Soggetti
Immunology
Journal title
Current opinion in immunology → ACNP
ISSN journal
09527915
Volume
6
Issue
2
Year of publication
1994
Pages
298 - 307
Database
ISI
SICI code
0952-7915(1994)6:2<298:TDAFIG>2.0.ZU;2-A
Abstract
The use of mice with defined genetic defects engineered by homologous recombination in embryonic stem cells has greatly enhanced our underst anding of immune functions at the single-gene level. The complex molec ular interactions involved in T-cell development and antigen recogniti on have been especially targeted for detailed analysis via knockout te chnology.