ON INDUCIBILITY AND FUNCTIONALITY OF THE INTERLEUKIN-6 RECEPTOR IN COMMON VARIABLE IMMUNODEFICIENCY (CVID)

Authors
JUNKER U FRITSCH A DIENER C VOGELSANG H
Citation
U. Junker et al., ON INDUCIBILITY AND FUNCTIONALITY OF THE INTERLEUKIN-6 RECEPTOR IN COMMON VARIABLE IMMUNODEFICIENCY (CVID), Allergologie, 17(2), 1994, pp. 39-43
Citations number
NO
Categorie Soggetti
Allergy
Journal title
Allergologie → ACNP
ISSN journal
03445062
Volume
17
Issue
2
Year of publication
1994
Pages
39 - 43
Database
ISI
SICI code
0344-5062(1994)17:2<39:OIAFOT>2.0.ZU;2-R
Abstract
We investigated the expression of the interleukin-6 receptor (IL-6R) o n B- and T-cells of patients suffering from CVID and normal healthy co ntrols before and after culture with pockeweed mitogen (PWM) and/or re combinant human interleukin-6 (IL-6) and the influence of the IL-6 on the production of immunoglobulins M and G (IgM, IgG). By correlating t he inducibility of the IL-6R and the effect of the IL-6 onto the produ ction of IgM and IgG a dysfunction of the IL-6/IL-6R system is propose d for at least two of the patients.