CD45-ISOTYPES ON LYMPHOCYTE SUBPOPULATION S IN COMMON VARIABLE IMMUNODEFICIENCY (CVID)

The expression of the CD45isotvpes CD45RA, CD45R0, and CD45RB on T cel l subpopulations in 26 patients suffering from CVID was investigated. In 20 out of these patients, the expression of CD45RA and CD45RB++ on CD4 cells was reduced. In the same patients, CD45R0 was raised. In the CD8 population, a inverse relation between CD45RA and CD45R0 was obse rved. In 14 patients, the CD45RB expression on CD4/CD45R0 and CD4/CD45 RA lymphocytes was studied by means of three color flowcytometry. In b oth populations, the number of cells with high density of CD45RB was r educed. The results are discusses in terms of activation and effector function of these cells.