A NEW SYNDROME OF FAMILIAL APLASTIC-ANEMIA AND CHRONIC LIVER-DISEASE

Authors
QAZILBASH MH LIU JM VLACHOS A FRUCHTMAN S MESSNER H ZIPURSKY A ALTER BP YOUNG NS
Citation
Mh. Qazilbash et al., A NEW SYNDROME OF FAMILIAL APLASTIC-ANEMIA AND CHRONIC LIVER-DISEASE, Acta haematologica, 97(3), 1997, pp. 164-167
Citations number
11
Categorie Soggetti
Hematology
Journal title
Acta haematologica → ACNP
ISSN journal
00015792
Volume
97
Issue
3
Year of publication
1997
Pages
164 - 167
Database
ISI
SICI code
0001-5792(1997)97:3<164:ANSOFA>2.0.ZU;2-2
Abstract
This report describes a new familial syndrome characterized by a combi nation of bone marrow failure and chronic liver disease. This disorder appears to be genetic in origin with an autosomal dominant inheritanc e and was characterized by hyperactivity of the immune system with inc reased activated cytotoxic T lymphocytes in peripheral blood and bone marrow and the presence of gamma-interferon messenger RNA in bone marr ow of several cases.