BETA-CYCLODEXTRIN INTERACTS WITH THE ALZHEIMER AMYLOID BETA-A4 PEPTIDE

Authors
CAMILLERI P HASKINS NJ HOWLETT DR
Citation
P. Camilleri et al., BETA-CYCLODEXTRIN INTERACTS WITH THE ALZHEIMER AMYLOID BETA-A4 PEPTIDE, FEBS letters, 341(2-3), 1994, pp. 256-258
Citations number
12
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
341
Issue
2-3
Year of publication
1994
Pages
256 - 258
Database
ISI
SICI code
0014-5793(1994)341:2-3<256:BIWTAA>2.0.ZU;2-4
Abstract
Electrospray ionisation mass spectrometry has been used to show that t he synthetic 40 amino acid beta-amyloid peptide (beta1-40) interacts w ith the cyclic oligosaccharide beta-cyclodextrin. This interaction, pr esumably with the hydrophobic aromatic moieties on the peptide, has be en shown to diminish substantially the neurotoxic effects of beta1-40 in a cell line.