TREATMENT OF BACTERIAL VAGINOSIS WITH A 3 DAY COURSE OF 2-PERCENT CLINDAMYCIN VAGINAL CREAM - A PILOT-STUDY

Objective-To evaluate the efficacy and safety of a 3 day course of 2% clindamycin cream in the treatment of bacterial vaginosis. Design-A pr ospective, randomised, double blind, placebo controlled study. Setting -Department of Genitourinary Medicine, Royal Liverpool University Hosp ital. Subjects-55 female patients aged 18 years and over, and premenop ausal, who spontaneously or after questioning complained of symptoms o f bacterial vaginosis.Results-55 patients were enrolled. 44 patients w ere evaluable at Visit 1 when among the 23 who received clindamycin cr eam bacterial vaginosis was not present in 22 (95.6%) and only one fai led treatment. Of the 21 patients in the placebo group only one (4.8%) patient was cured and 20 (95.2%) were failures. Of the 17 patients ev aluable at Visit 2 in the clindamycin group, bacterial vaginosis was n ot present in 14 (82.4%) and had recurred in three. No serious adverse events were noted in either group. Conclusion-This pilot study provid es encouraging evidence of the efficacy and safety of a 3 day course o f 2% clindamycin cream in bacterial vaginosis.