BEHAVIORAL IMPAIRMENT INDUCED BY CALCITONIN-GENE-RELATED PEPTIDE (CGRP) ANTISERUM IN PASSIVE-AVOIDANCE REFLEX IN RATS

Authors
KOVACS A TELEGDY G
Citation
A. Kovacs et G. Telegdy, BEHAVIORAL IMPAIRMENT INDUCED BY CALCITONIN-GENE-RELATED PEPTIDE (CGRP) ANTISERUM IN PASSIVE-AVOIDANCE REFLEX IN RATS, Neuropeptides, 26(4), 1994, pp. 233-236
Citations number
32
Categorie Soggetti
Neurosciences,"Endocrynology & Metabolism
Journal title
Neuropeptides → ACNP
ISSN journal
01434179
Volume
26
Issue
4
Year of publication
1994
Pages
233 - 236
Database
ISI
SICI code
0143-4179(1994)26:4<233:BIIBCP>2.0.ZU;2-K
Abstract
The effects of CGRP antiserum on passive avoidance behaviour were test ed in rats. Intracerebroventricular (i.c.v.) administration of CGRP an tiserum immediately after a single learning trial attenuated the passi ve avoidance responses when the animals were tested for 24 h retention . Significant decreases in avoidance latency were found at CGRP antise rum dilutions of 1 : 20 and 1 : 40. The data supported the assumption that endogenous brain CGRP may be a modulator in learning-associated m emory processes.