ANTITUMOR-ACTIVITY OF (TRANS)DERMALLY DELIVERED AROMATIC TETRA-AMIDINES

The present work describes the design and preparation of lecithin micr oemulsion gels containing the aromatic tetra-benzamidine (TAPP-Br) and the antitumor evaluation of this topical formulation on nude mice xen ografted with the highly tumorigenic cell line FH06T1-1, in comparison to the antitumor activity of TAPP-Br administered by intraperitoneal injections (0.5 mg/injection). After (trans) dermal treatment with 0.1 ml lecithin gels incorporating TAPP-Br (0.2 mg/ml), a reduction of in vivo tumor cell growth was observed. These results could be of great interest with a view to developing a releasing system useful for exper imental chemotherapy of tumor lesions occurring at cutaneous or subcut aneous level.