BIOCHEMICAL EVALUATION OF THE ANTIULCEROGENIC EFFECT OF CAUVERY-100 (AN AYURVEDIC FORMULATION) IN RATS

Due to the varied pathogenesis of ulcers, a number of pharmacologicall y different antiulcer drugs are now used in the treatment of the condi tion. The suitability of certain of these drugs is still to be establi shed. Cauvery-100 is an ayurvedic formulation consisting of plant ingr edients, and has been suggested to be useful in the treatment of gastr ointestinal disorders. In the present study this drug was tested for i ts antiulcerogenic effect. The number of lesions on gastric mucosa dec reased markedly after 15 days oral treatment with Cauvery-100 in rats with indomethacin-induced ulcers. The volume and total acidity of the gastric juice also decreased in the treated rats. The hexose, hexosami ne and sialic acid levels of gastric contents, which were increased in untreated rats returned to near normal levels after 15 days of treatm ent. Protein in the gastric juice was elevated in untreated rats but r eturned to near normal levels after 15 days of treatment. Cauvery-100 acts both to decrease the acidity and to increase the mucosal defence in the gastric areas, thereby justifying its use as an antiulcerogenic agent.