Demands for less invasive, more cost-effective therapy have revolution
ized the management of gallstones over the past 10 years. There are no
reliable methods of permanently reversing the pathophysiologic defect
s that cause gallstones. Open cholecystectomy (OC), the gold standard
for managing symptomatic cholelithiasis, has been largely replaced by
laparoscopic cholecystectomy (LC), which has the advantages of a minim
al hospital stay and quicker return to work. Other adjunctive therapie
s, limited in applicability to selected patients, include oral bile ac
id therapy (BAT), dissolutional agents, and extracorporeal shock wave
lithotripsy. Choledocholithiasis (CDL), formerly managed exclusively w
ith surgical common duct exploration, is increasingly treated with the
rapeutic biliary endoscopy. Methods of laparoscopic common bile duct e
xploration are being developed. Optimal algorithms for applying these
techniques to patients undergoing LC are evolving. In a sense, the sol
ution to all, or certainly most, gallstones now can be seen through a
scope.