DELTA(22)-BETA-MURICHOLIC ACID IN MONOASSOCIATED RATS AND CONVENTIONAL RATS

Authors
KAYAHARA T TAMURA T AMURO Y HIGASHINO K IGIMI H UCHIDA K
Citation
T. Kayahara et al., DELTA(22)-BETA-MURICHOLIC ACID IN MONOASSOCIATED RATS AND CONVENTIONAL RATS, Lipids, 29(4), 1994, pp. 289-296
Citations number
32
Categorie Soggetti
Biology
Journal title
Lipids → ACNP
ISSN journal
00244201
Volume
29
Issue
4
Year of publication
1994
Pages
289 - 296
Database
ISI
SICI code
0024-4201(1994)29:4<289:DAIMRA>2.0.ZU;2-8
Abstract
Bile acids were analyzed in the bile, small and large intestines, and feces of germ-free rats after a single inoculation with one of six int estinal bacteria that had been originally isolated from human feces. B acteroides vulgatus and Bifodobacterium longum preferentially deconjug ated tauro-beta-muricholic acid and taurocholic acid, respectively. Cl ostridium ramosum, Peptostreptococcus productus and Lactobacillus gass eri deconjugated both bile acids, but Escherichia coli did not deconju gate either one. Rats inoculated with bacteria that deconjugated tauro -beta-muricholic acid produced Delta(22)-beta-muricholic acid in the f eces. In contrast, Delta(22)-cholic acid could not be detected in rats inoculated with bacteria that deconjugated taurocholic acid.