COMPARISON OF THE EFFICACY OF SPIRANOLACTONE VERSUS FLUTAMIDE IN THE TREATMENT OF HIRSUTISM

Citation
M. Erenus et al., COMPARISON OF THE EFFICACY OF SPIRANOLACTONE VERSUS FLUTAMIDE IN THE TREATMENT OF HIRSUTISM, Fertility and sterility, 61(4), 1994, pp. 613-616
Citations number
15
Categorie Soggetti
Obsetric & Gynecology
Journal title
ISSN journal
00150282
Volume
61
Issue
4
Year of publication
1994
Pages
613 - 616
Database
ISI
SICI code
0015-0282(1994)61:4<613:COTEOS>2.0.ZU;2-7
Abstract
Objective: To compare the efficacy of two antiandrogens, spironolacton e and flutamide, in the treatment of hirsutism. Patients, Participants : Twenty women with idiopathic hirsutism were randomized to receive ei ther flutamide or spironolactone. Design: Twenty hirsute women were re cruited from patients presenting to the hirsutism clinic in Marmara Un iversity, Istanbul. Each patient underwent a complete medical and gyne cological examination as well as endocrine profile, hematologic, hepat ic, and renal function analyses. Hirsutism scores were determined acco rding to the Ferriman-Gallwey scoring system. These tests were then re peated at 3, 6, and 9 months of therapy. Ten patients received 250 mg of flutamide two times per day, and 10 patients received 100 mg of spi ronolactone for 9 months. Results: Ferriman-Gallwey scores were decrea sed significantly in both groups at the end of 9 months. The percent o f change in hirsutism scores in flutamide and spironolactone group wer e as follows: 26.4% and 20.9% at 3 months; 39.5% and 32.9% at 6 months ; and 46.4% and 39.6% at 9 months, respectively. There was a trend tow ard a better response with flutamide that did not achieve significance . None of the hormonal parameters changed significantly during this pe riod of time. Irregular bleeding was observed in five patients (50%) o f the spironolactone group, whereas none of the patients in the flutam ide group experienced menstrual irregularity. Conversely, dry skin and increased appetite were experienced by two patients (20%) in the flut amide group but not in the spironolactone group. Conclusion: These dat a suggest that both spironolactone and flutamide were similarly effect ive in treatment of hirsutism, and the pure antiandrogen flutamide is a safe and effective alternative in treatment.