RESOLUTION OF SYNTHETIC (-EPIBATIDINE AND (-)-EPIBATIDINE BY CHIRAL HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY AND IDENTIFICATION OF THE NATURAL ENANTIOMER())

Authors
WATT AP VERRIER HM OCONNOR D
Citation
Ap. Watt et al., RESOLUTION OF SYNTHETIC (-EPIBATIDINE AND (-)-EPIBATIDINE BY CHIRAL HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY AND IDENTIFICATION OF THE NATURAL ENANTIOMER()), Journal of liquid chromatography, 17(6), 1994, pp. 1257-1264
Citations number
5
Categorie Soggetti
Chemistry Analytical
Journal title
Journal of liquid chromatography → ACNP
ISSN journal
01483919
Volume
17
Issue
6
Year of publication
1994
Pages
1257 - 1264
Database
ISI
SICI code
0148-3919(1994)17:6<1257:ROS(A(>2.0.ZU;2-2
Abstract
Methods are described for the separation of the enantiomers (+)- and ( -)-epibatidine and (+)- and (-)-N-acetylepibatidine by high performanc e liquid chromatography using Chiral-AGP and Chiralcel OD chiral stati onary phases respectively. Comparison of synthetic material with authe ntic epibatidine. HCl using retention times and UV spectra allows the unambiguous assignment of the natural product as the (+)-isomer.