SEPARATION AND DETERMINATION OF CARBADOX, NITROFURAZONE, NITROFURANTOIN, FURAZOLIDONE, AND FURALTADONE IN THEIR MIXTURES BY THIN-LAYER AND HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

The separation and quantitative determination of five drugs, namely ca rbadox, nitrofurazone, nitrofurantoin, furazolidone and furaltadone, i n their various mixtures of 3, 4 or 5 components was investigated. Two types of mobile phases were examined for the TLC separation of the dr ugs, chloroform/ acetonitrile/formic acid and chloroform/acetone. Two other mobile phases were also examined for the high performance liquid chromatographic determination of them, acetonitrile/sodium acetate an d acetonitrile/sodium dihydrogen phosphate. The resolution of the chro matograms was studied in both cases and also the regression lines of t he quantitative determination were described. The absolute detection l imits of the determination were in the range of 0.2-1.6 ng for the fiv e compounds.