CA125-PRODUCING ADENOCARCINOMA OF THE SEMINAL-VESICLE

A case of primary seminal vesicle carcinoma is reported. The tumor was a CA125-producing adenocarcinoma consisting of fine papillary-tubular , intricate branching or anastomosing glandular structures and was com posed of small cuboidal, but occasionally hobnailed, cells with mostly clear, but occasionally granular, cytoplasm. Some tumor cells showed evidence of secretion of seromucinous materials into the interpapillar y and cystic space. Immunohistochemically, almost half of the tumor ce lls expressed a positive reaction with anti-CA125, a common serologica l marker for ovarian epithelial carcinomas; however, no tumor cells ex pressed any other serological tumor markers such as carcinoembryonic a ntigen, alpha-fetoprotein, human chorionic gonadotropin, prostatic spe cific acid phosphatase, or prostatic specific antigen. The patient sho wed a high level of serological CA125, which fluctuated parallel with the growth, removal and recurrence of the tumor. The morphological and immunohistochemical findings suggested a close relationship between t he present tumor and clear cell carcinoma of the ovary, which is thoug ht to be of a Mullerian-Wolfian duct origin.