Ik. Mohan et Un. Das, OXIDANT STRESS, ANTIOXIDANTS AND NITRIC-OXIDE IN NON-INSULIN-DEPENDENT DIABETES-MELLITUS, Medical science research, 25(1), 1997, pp. 55-57
In patients with non-insulin-dependent diabetes mellitus (NIDDM) there
is believed to be an imbalance between oxidants and anti-oxidants. Th
is is likely to lead to endothelial dysfunction, which may predispose
patients to the development of atherosclerosis and target organ damage
. Here we present evidence that in patients with NIDDM, the levels of
lipid peroxides are high, with a simultaneous decrease in those of sup
eroxide dismutase, vitamin E, glutathione peroxidase and reductase and
nitric oxide. Hence efforts to enhance nitric oxide and restore antio
xidants to normal levels and decrease lipid peroxidation process may b
e of benefit in NIDDM.