TESTICULAR HISTOLOGY AFTER TREATMENT WITH THE NEW ANTIANDROGEN CASODEX FOR CARCINOMA OF THE PROSTATE - A PRELIMINARY-REPORT

Citation
Teb. Johansen et al., TESTICULAR HISTOLOGY AFTER TREATMENT WITH THE NEW ANTIANDROGEN CASODEX FOR CARCINOMA OF THE PROSTATE - A PRELIMINARY-REPORT, Scandinavian journal of urology and nephrology, 28(1), 1994, pp. 67-70
Citations number
9
Categorie Soggetti
Urology & Nephrology
ISSN journal
00365599
Volume
28
Issue
1
Year of publication
1994
Pages
67 - 70
Database
ISI
SICI code
0036-5599(1994)28:1<67:THATWT>2.0.ZU;2-6
Abstract
Five men aged 55-78 years, had received Casodex 50 mg p.o. daily for s even to 12 months. Because of tumour progression orchiectomy was perfo rmed. All testes were examined with light- and electronmicroscopy. Evi dence of Leydig cell hyperplasia was present in testes from three pati ents. However, the ultrastructural appearance of the Leydig cells was normal. The spermatogenesis was reduced in all testes, although not si gnificantly different from controls. We believe the Leydig cell hyperp lasia reflects an increased profliferative stimulation by luteinizing hormone or a direct effect of Casodex.