Teb. Johansen et al., TESTICULAR HISTOLOGY AFTER TREATMENT WITH THE NEW ANTIANDROGEN CASODEX FOR CARCINOMA OF THE PROSTATE - A PRELIMINARY-REPORT, Scandinavian journal of urology and nephrology, 28(1), 1994, pp. 67-70
Five men aged 55-78 years, had received Casodex 50 mg p.o. daily for s
even to 12 months. Because of tumour progression orchiectomy was perfo
rmed. All testes were examined with light- and electronmicroscopy. Evi
dence of Leydig cell hyperplasia was present in testes from three pati
ents. However, the ultrastructural appearance of the Leydig cells was
normal. The spermatogenesis was reduced in all testes, although not si
gnificantly different from controls. We believe the Leydig cell hyperp
lasia reflects an increased profliferative stimulation by luteinizing
hormone or a direct effect of Casodex.