DETECTION OF POINT MUTATIONS BY SOLID-PHASE METHODS

Authors
SYVANEN AC LANDEGREN U
Citation
Ac. Syvanen et U. Landegren, DETECTION OF POINT MUTATIONS BY SOLID-PHASE METHODS, Human mutation, 3(3), 1994, pp. 172-179
Citations number
68
Categorie Soggetti
Genetics & Heredity
Journal title
Human mutation → ACNP
ISSN journal
10597794
Volume
3
Issue
3
Year of publication
1994
Pages
172 - 179
Database
ISI
SICI code
1059-7794(1994)3:3<172:DOPMBS>2.0.ZU;2-H
Abstract
Several techniques exist that permit the efficient distinction among c haracterized DNA sequence variants, In this review we discuss a number of such analytic procedures. These techniques all take advantage of a variety solid supports to prepare and analyze reaction products. The described diagnostic principles are now being applied for the developm ent of miniaturized assay formats, suitable for automated detection of large sets of sequences in clinical samples. (C) 1994 Wiley-Liss, Inc .