PENDENT CHAIN-LINKED DELIVERY SYSTEMS .2. FACILE HYDROLYSIS THROUGH MOLECULAR IMPRINTING EFFECTS

Citation
Rn. Karmalkar et al., PENDENT CHAIN-LINKED DELIVERY SYSTEMS .2. FACILE HYDROLYSIS THROUGH MOLECULAR IMPRINTING EFFECTS, Journal of controlled release, 43(2-3), 1997, pp. 235-243
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
ISSN journal
01683659
Volume
43
Issue
2-3
Year of publication
1997
Pages
235 - 243
Database
ISI
SICI code
0168-3659(1997)43:2-3<235:PCDS.F>2.0.ZU;2-X
Abstract
In an earlier communication we reported the synthesis of hydrogels con taining an imidazole group and the polymer conjugate which formed a ch arge transfer complex. The catalytic activity of imidazole enhanced th e rate of release of p-nitrophenol. To further extend this approach to polymer conjugates which cannot form such complexes, we now show how the functional groups in such cases can be brought in proximity by met al-ion coordination and molecular imprinting techniques. The hydrolysi s of the inactive esters from these hydrogels takes place under facile conditions and is pH responsive.