Rn. Karmalkar et al., PENDENT CHAIN-LINKED DELIVERY SYSTEMS .2. FACILE HYDROLYSIS THROUGH MOLECULAR IMPRINTING EFFECTS, Journal of controlled release, 43(2-3), 1997, pp. 235-243
In an earlier communication we reported the synthesis of hydrogels con
taining an imidazole group and the polymer conjugate which formed a ch
arge transfer complex. The catalytic activity of imidazole enhanced th
e rate of release of p-nitrophenol. To further extend this approach to
polymer conjugates which cannot form such complexes, we now show how
the functional groups in such cases can be brought in proximity by met
al-ion coordination and molecular imprinting techniques. The hydrolysi
s of the inactive esters from these hydrogels takes place under facile
conditions and is pH responsive.