Ductal adenoma of the breast may simulate malignancy by both clinical,
histological, and cytological examination. Fine-needle aspirations fr
om breast lesions are now daily routine and preoperative recognition o
f this benign lesion is desirable. This study describes the cytologic
features of six additional cases of ductal adenoma. The smears from al
l the lesions were highly cellular with epithelial cells in sheets. Nu
merous large fragments of purple stroma in tight connection with epith
elial cells often making finger-like hyaline structures or globules be
tween cells were seen. Naked oval nuclei in the background were observ
ed in all cases indicating benignancy. We find the cytologic picture i
n fine-needle aspirations from ductal adenomas sufficiently characteri
stic for preoperative diagnosis. The differential diagnoses toward oth
er benign and malignant conditions are discussed. (C) 1994 Wiley-Liss,
Inc.