Sj. Maygarden et al., FINE-NEEDLE ASPIRATION CYTOLOGY OF SUTURE GRANULOMAS OF THE BREAST - A POTENTIAL PITFALL IN THE CYTOLOGIC DIAGNOSIS OF RECURRENT BREAST-CANCER, Diagnostic cytopathology, 10(2), 1994, pp. 175-179
The fine-needle aspirates of three cases of suture granulomas of the b
reast area following mastectomy, lumpectomy, or axillary node dissecti
on were reviewed. The original histologic diagnoses were mucinous (col
loid) carcinoma, intraductal carcinoma, and low-grade phyllodes tumor.
In two patients a new nodule developed in the surgical scar, and in t
he third a nodule developed in the axilla 2 cm away from the scar. The
cellularity of the aspirates ranged from low to moderate, and all thr
ee cases contained variable numbers of spindled cells and fragments of
cellular stroma. Multinucleated giant cells characteristic of suture
granulomas were absent in all cases. Abundant metachromatic amorphous
background material was present in one case, which was interpreted as
recurrent mucinous carcinoma. The remaining cases were interpreted as
suspicious for recurrent neoplasm. Upon excision, all were suture gran
ulomas with fibroblastic proliferation. Suture granulomas can both cli
nically and cytologically mimic recurrent malignancy. The predominance
of spindled cells and dissimilarity to the original tumor appear to b
e the most helpful features to cytologically distinguish suture granul
oma from recurrent carcinoma in the absence of the characteristic mult
inucleated giant cells. (C) 1994 Wiley-Liss, Inc.