CREATINE KINASE-MB - DETECTION OF MYOCARDIAL-INFARCTION AND MONITORING REPERFUSION

Creatine kinase-MB (CK-MB), although not cardiac specific, is the enzy me currently used as the definitive serum marker for the diagnosis or exclusion of acute myocardial infarction (AMI). This article reviews t he diagnostic characteristics of CK-MB, including the clinical implica tions of serial and single CK-MB levels, a quality assurance monitor f or optimal use of CK-MB and lactate dehydrogenase (LD) isoenzyme testi ng in myocardial infarction and reperfusion, and the methods and limit ations of monoclonal anti-CK-MB antibody based immunoassays.