IN-VIVO ERADICATION OF FRIEND-VIRUS AS AN EXPERIMENTAL HIV-MODEL, BY COMBINATION OF ZIDOVUDINE, ACRIFLAVINE AND AN ELLIPTICINE ANALOG - POSSIBLE APPLICATION TO THE TREATMENT OF HUMAN PRE-AIDS

Simultaneous administration of zidovudine, acriflavine and celliptium to Friend virus-injected mice eradicates the virus, as evidenced by th e impossibility of the treated-mouse serum, when injected to virgin re cipients, to induce spleen foci formation. An adapted preliminary prot ocol given to patients in whose p 24 antigen was present in the blood, lead to a considerable reduction of that marker. The cures lasted 3 w eeks, and were repeated after 3 week intervals. Since p 24 antigen ret urns to pre-treatment levels at the end of the interval, research shou ld concentrate on the maintenance of the effect during the interval.