RELATIONSHIP BETWEEN THE SUPPRESSIVE ACTIONS ON INTESTINAL-ABSORPTIONAND ON CGMP PRODUCTION FOR THE NATRIURETIC PEPTIDE FAMILY IN DOGS

1. The aim of this study was to investigate whether the suppressive ef fects of atrial natriuretic peptide (ANP), brain natriuretic peptide ( BNP) and C-type natriuretic peptide (CNP) on net intestinal absorption were related to guanosine 3',5'-cyclic monophosphate (cGMP) productio n in the intestine. 2. We measured the plasma cGMP concentration of th e arterial, jejunal and ileal venous blood after intravenous infusions of natriuretic peptides (97 pmol/kg per min for 30 min) in anaestheti zed dogs. 3. The infusion of ANP increased cGMP concentration of the a ortic blood by 49.9+/-9.0 (pmol/mL), BNP by 71.8+/-12.3 and CNP by 5.5 +/-1.3. The increases in cGMP after ANP and BNP were larger than after CNP. The infusion of ANP increased jejunal arteriovenous differences in cGMP concentration by 69.9+/-3.5 (pmol/mL) and ileal arteriovenous differences by 8.7+/-3.2. In BNP infusion, the jejunal and ileal arter iovenous differences in cGMP concentration tended to increase by 15.6/-5.8 (pmol/mL) and by 14.8+/-6.6 but neither were significant. CNP in fusion did not change the jejunal and ileal arteriovenous differences in cGMP concentration. 4. These results suggest that, while the action s of ANP on intestinal absorption may be mediated by cGMP, those of BN P and CNP are not.