MECHANISMS OF THE PRESSOR-RESPONSE TO INTRAVENOUS THYROTROPIN-RELEASING-HORMONE IN THE RAT

Authors
EVEQUOZ D BURNIER M NIEDERBERGER M BRUNNER HR NUSSBERGER J WAEBER B
Citation
D. Evequoz et al., MECHANISMS OF THE PRESSOR-RESPONSE TO INTRAVENOUS THYROTROPIN-RELEASING-HORMONE IN THE RAT, Clinical and experimental pharmacology and physiology, 21(2), 1994, pp. 93-100
Citations number
30
Categorie Soggetti
Pharmacology & Pharmacy",Physiology
Journal title
Clinical and experimental pharmacology and physiology → ACNP
ISSN journal
03051870
Volume
21
Issue
2
Year of publication
1994
Pages
93 - 100
Database
ISI
SICI code
0305-1870(1994)21:2<93:MOTPTI>2.0.ZU;2-S
Abstract
1. The purpose of this study was to examine the contribution of the sy mpatho-adrenomedullary system to the blood pressure response to an int ravenous bolus of thyrotropin-releasing hormone (TRH) in conscious med ullectomized and sham-operated rats. 2. The peak presser effect of 0.5 mg TRH was significantly increased in rats having no adrenal medulla (+24.2+/-1.6 mmHg, mean+/-s.e.m., P<0.01) as compared to sham-operated animals (+12.2+/-3.0 mmHg).