Nm. Sanghavi et al., SOLUBILIZATION OF GLIBENCLAMIDE WITH BETA-CYCLODEXTRIN AND ITS DERIVATIVES, Drug development and industrial pharmacy, 20(7), 1994, pp. 1275-1283
Glibenclamide, a widely used potent hypoglycaemic agent was solubilize
d using beta -Cyclodextrin and beta -Cyclodextrin derivatives. Complex
es were prepared by kneading method in a molar ratio of 1:1 of the dru
g and the cyclodextrins respectively. The Glibenclamide beta-Cyclocext
rin complex was characterized and evaluated by I.R. studies, Different
ial Scanning Calorimetry & X-ray diffractometry. The in-vitro dissolut
ion rates of drug from inclusion complexes of beta - Cyclodextrins and
its derivatives were compared. A significant improvement in dissoluti
on rates of Glibenclamide was observed with inclusion complexes of all
the Cyclodextrins. However, the solubilizing effect was more in case
of beta-Cyclodextrin derivatives.