EFFECT OF MK-571, A SELECTIVE LEUKOTRIENE D-4 RECEPTOR ANTAGONIST, ONVASCULAR SMOOTH-MUSCLE CELL-PROLIFERATION AND INTERLEUKIN-1 RELEASE

Authors
PORRECA E REALE M DIFEBBO C BARBACANE RC CASTELLANI ML CIPOLLONE F CARRATELLI L CONTI P CUCCURULLO F
Citation
E. Porreca et al., EFFECT OF MK-571, A SELECTIVE LEUKOTRIENE D-4 RECEPTOR ANTAGONIST, ONVASCULAR SMOOTH-MUSCLE CELL-PROLIFERATION AND INTERLEUKIN-1 RELEASE, International journal of immunopathology and pharmacology, 7(1), 1994, pp. 57-64
Citations number
32
Categorie Soggetti
Pharmacology & Pharmacy",Immunology,Pathology
Journal title
International journal of immunopathology and pharmacology → ACNP
ISSN journal
03946320
Volume
7
Issue
1
Year of publication
1994
Pages
57 - 64
Database
ISI
SICI code
0394-6320(1994)7:1<57:EOMASL>2.0.ZU;2-D
Abstract
Recent studies suggest the involvement of inflammatory mechanisms in t he progression of atherosclerosis. Coculturing cysteinyl leukotriene D -4 with vascular smooth muscle cells (VSMC) produced an increased cell proliferation, as assessed by [H-3]-Thymidine incorporation studies, as well as cell count. MK-571, a specific leukotriene D-4 (LTD(4)) rec eptor antagonist, inhibited the mitogenic effect induced by LTD(4). Fu thermore the autocrine production of interleukin-1 (IL-1), concomitant to LTD, stimulation, was again controlled by MK-571. A new role for M K-571 may possibly be suggested in the control of the atherogenic proc ess.