2-(METHYLENEAMINOXY)METHYLMORPHOLINE DERIVATIVES - SYNTHESIS AND ANTIDEPRESSANT ACTIVITY

The 3-(methyleneaminoxy)methylmorpholines 2 were synthesized as analog ues of viloxazine I, an antidepressant drug, in which the aryloxymethy l group is substituted by a (methyleneaminoxy)methyl moiety (MAOMM). C ompounds 2 were tested as potential antidepressant agents by using the test of antagonism to reserpine-induced hypothermy in mice. In additi on, their anticholinergic and antihistaminic activity on isolated prep arations and their ability to antagonize the toxicity induced by adren aline in mice were evaluated. ''In vivo'' and ''in vitro'' tests showe d that some compounds of type 2 possess a pharmacological profile simi lar to that of viloxazine 1.